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Experimental Drug Offers New Hope for Heart Valve Disease Treatment

An experimental drug originally developed by Sanofi that is now being advanced by the Mayo Clinic significantly curbed progression of aortic valve stenosis, a common heart problem, in clinical trials, potentially preventing the need for surgery. Aortic valve stenosis, a narrowing due to calcium deposits that forces the heart to work harder to move blood to the body, currently can only be monitored until the condition becomes severe enough to warrant valve replacement surgery. The drug ataciguat has been tested in early and mid-stage trials of patients with moderate aortic valve stenosis.

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